INVESTIGATION OF CELANDINE EXTRACTS (CHELIDONIUM MAJUS L.) BY 1H NMR AND QNMR METHODS

The analysis of Celandine extracts (Chelidonium majus L.) by 1H NMR method makes it possible to identify the main alkaloids – derivatives phenanthridine, protoberberin and protopin, use qNMR provides information with satisfactory accuracy about content these alkaloids. determined in composition (0.35%) is 2 times lower than when using spectrophotometric determination procedure described GF Russian Federation XIV (0.72%). extraction results according methods given State Pharmacopoeia edition USSR IX give similar results: same are found chelidonin, stylopine protopine, total 1.6-1.8 less extracting raw material samples insistence. When extracted infusion, dihydrosanguinarin, stylopine, berberine coptisin.